Editorial Compilation—Part XVIII

Welcome to the latest issue of "Seminars in Thrombosis and Hemostasis (STH)" published under the "banner" of "Editorial Compilation," this being the 18th such issue (Table 1).Historically, "STH" is a theme-driven publication; however, ongoing opportunities emerge to disseminate wide-ranging contributions of current interest or controversy, which do not directly suit an ongoing themed issue.We also require a medium to enable publication of peer-reviewed "unsolicited" manuscripts if accepted, as well as contributions from our Eberhard F. Mammen Young Investigator Award winners (see Table 2 for previous Editorials related to the Eberhard F. Mammen awards).As is now standard for this compilation series, this study contains a mixture of articles that comprise the above elements, as well as broadly fitting within the standard themes of "thrombosis" and "bleeding."This issue begins with a review on disseminated intravascular coagulation (DIC) by Iba et al, 1 who introduce the readers of STH to the new definition and diagnostic criteria recently released by the International Society on Thrombosis and Haemostasis.The new guidance reflects advances in understanding the pathophysiology of DIC, which is now defined as an acquired, life-threatening condition involving systemic coagulation activation, impaired fibrinolysis, and endothelial injury.The revised framework emphasizes the condition's dynamic nature, progressing from preclinical abnormalities to overt clinical manifestations such as bleeding and (multiple) organ dysfunction.A major innovation in the 2025 update is the phase-based classification of DIC: pre-DIC, early phase DIC, and overt DIC.Early phase DIC-also referred to as subclinical