Diagnostic value and role in promoting fracture healing of deregulated circulating miR-204 in patients with osteoporotic fractures
Elevating miR-204 promotes OPF development and impairs BMSC-mediated osteogenic differentiation and repair of fractures, warranting further in vivo validation. Inhibition of miR-204 may enhance osteogenic differentiation and fracture healing, representing a potential avenue for future therapeutic investigation in OPF.
Authors
- Liang Han (ORCID: https://orcid.org/0000-0003-3578-2914)
- Chen Shao (ORCID: https://orcid.org/0000-0002-6899-5353)
- Xiaowei Jiang
- Jianfei Cao
- Jin Li
- Jiaojiao Chen
- Zhiqiang Cheng
- Lei Shang
- Jingjing Liu
Institutions
- Jiangsu University (CN)
- Zhangjiakou Academy of Agricultural Sciences (CN)
- Xuzhou Cancer Hospital (CN)
- Xuzhou Central Hospital (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- Maternal and Child Health Hospital of Xuzhou (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1186/s13018-025-06652-9
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00