Neurochemical Analysis of the Effect of the Combination of Ladasten with Fabomotizole on the Dopaminergic System of the Mouse Brain in 6-Hydroxydophamine Model of Parkinsonian Syndrome

In this study, we performed a neurochemical analysis of the content of dopamine and its metabolites in the striatum of mice after oral daily administration for 14 days of the combination of ladasten (10, 50, 100 mg/kg) with fabomotizole (5–10 mg/kg) on a model of Parkinsonian syndrome induced by unilateral intrastriatal injection of 6-hydroxydophamine (6-OHDA). The combination of ladasten with fabomotizole successfully prevented a decrease in the content of dopamine and its metabolites in the damaged 6-OHDA striatum of mice, while the greatest effectiveness was observed when combined drugs were given at high doses: ladasten 100 and 50 mg/kg with fabomotizole 5 and 10 mg/kg. At the same time, the combination of a lower dose of ladasten 10 mg/kg and with the highest dose of fabomotizole 10 mg/kg showed more effectiveness than the combination of 10 mg/kg ladasten with 5 mg/kg fabomotizol. The studied effect of the combination of ladasten with fabomotizole on the dopaminergic system of the mouse brain can be characterized as synergistic dopamine-positive, which determines the therapeutic potential of this combination.