Bloodstream infection with NDM-1/5 Enterobacter cloacae complex in China: diverse STs, multi-virulence systems and carbapenem resistance
Our institutional CRECC-BSI is characterized by diverse sequence types, a complex plasmid profile and a high burden of virulence genes; ST171 is the dominant clone and <i>bla</i> <sub>NDM-1</sub> the principal carbapenemase. Close surveillance of this high-risk lineage and of IncX3/IncHI2-mediated horizontal gene transfer is essential, together with strengthened infection-control and antimicrobial-stewardship measures.
Authors
- Zhijun Zhang (ORCID: https://orcid.org/0000-0002-5470-9491)
- Yuan Wang (ORCID: https://orcid.org/0000-0002-7355-9505)
- Chunhong Shao
- Yujing Tian
- Qun Zhang
- Yan Jin
Institutions
- Qingdao University (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Taian City Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fcimb.2025.1738317
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province