Multiomics reveals epigenetic control of fibroblast activity after myocardial infarction and a key role for RUNX transcription factors
Cardiac fibroblast activation and differentiation after MI are regulated by dynamic epigenetic changes. <i>Runx1</i> plays a pivotal role in modulating cardiac fibroblast activities, and its deletion improves cardiac repair by mitigating maladaptive fibroblast responses. By illuminating the centrality of <i>Runx1</i> in post-MI repair, this study identifies an actionable pathway for therapeutically steering fibroblast responses.
Authors
- Nishan Khatri
- Leshan Wang
- Mohammad Shiri (ORCID: https://orcid.org/0000-0003-0118-1432)
- Joseph Francis (ORCID: https://orcid.org/0000-0002-9502-4579)
- Constantine A. Simintiras (ORCID: https://orcid.org/0000-0001-5123-258X)
- Qianglin Liu (ORCID: https://orcid.org/0000-0002-3234-9157)
- YUXIA LI
- Jiangwen Sun
- Xujia Zhang
- Sachin Upadhayaya
- Xing Fu
- Rayyan Shakoori
- Kishan Ghimire
- Boyu Li
- Rui Li
Institutions
- Louisiana State University (US)
- Louisiana State University Agricultural Center (US)
- University of Massachusetts Chan Medical School (US)
- Old Dominion University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-13
- DOI
- https://doi.org/10.64898/2026.01.12.699153
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00