Medial Temporal Lobe Dynamic Network Flexibility is Reduced Among Autosomal Dominant Alzheimer's Disease Mutation Carriers

Among ADAD mutation carriers, reduced MTL dynamic network flexibility suggesting early functional changes despite no significant differences in subfield volumes. Additionally, larger right entorhinal cortex volume was associated with better cognitive performance, highlighting its role in preserving cognitive function. These findings suggest that dynamic functional network alterations within the MTL region may serve as early indicators of disease progression in ADAD, even before structural atrophy becomes apparent. This study also underscores the need for integrating network-based and subfield-specific analyses while considering ADAD mutation status to better understand disease mechanisms.