Syndrome‐specific and familial imaging traits in juvenile absence epilepsy
Our findings in JAE differ from the patterns of functional reorganization reported in JME, indicating that each syndrome involves distinct motor-cognitive pathophysiological mechanisms aligned with its seizure profile. Inferior frontal structural abnormalities likely contribute to the well-recognized language difficulties in JAE, whereas increased midcingulate gray matter volume may serve as a familial marker linked to attentional vulnerability.
Authors
- Lorenzo Caciagli (ORCID: https://orcid.org/0000-0001-7189-9699)
- Lawrence P. Binding (ORCID: https://orcid.org/0000-0002-5658-4960)
- Britta Wandschneider (ORCID: https://orcid.org/0000-0001-7181-2637)
- J Duncan
- Louis A. van Graan (ORCID: https://orcid.org/0000-0003-0531-9259)
- Matthias J. Koepp (ORCID: https://orcid.org/0000-0002-4277-8000)
- Dominic Heaney (ORCID: https://orcid.org/0000-0003-1508-9004)
- Davide Giampiccolo (ORCID: https://orcid.org/0000-0003-3849-4168)
- Marine Fleury (ORCID: https://orcid.org/0000-0002-9947-0322)
- Maria Virginia Centeno (ORCID: https://orcid.org/0000-0002-9470-6543)
- Luisa Delazer (ORCID: https://orcid.org/0009-0002-1330-3628)
- Karin Trimmel
- Josemir W. Sander
- Fenglai Xiao
- Sanjeev Rajakulendran
- Sjoerd Vos
Institutions
- Innsbruck Medical University (AT)
- The University of Western Australia (AU)
- Universität Innsbruck (AT)
- University Hospital of Bern (CH)
- LMU Klinikum (DE)
- National Imaging Facility (AU)
- Hospital Clínic de Barcelona (ES)
- Laboratoire d’Imagerie Biomédicale (FR)
- Cleveland Clinic London (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- North Middlesex Hospital (GB)
- Stichting Epilepsie Instellingen Nederland (NL)
- University College London (GB)
- Epilepsy Society (GB)
- Middlesex University London (GB)
- Medical University of Vienna (AT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1002/epi.70094
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00