Mediterranean diet adherence and tirzepatide: real-world evidence on adiposity indices and insulin resistance beyond weight loss
This real-world study confirms the efficacy of tirzepatide on adiposity and metabolic markers and provides exploratory evidence that adherence to a Mediterranean diet enhances its impact on visceral adiposity. The combination of pharmacological therapy and diet quality may offer additive benefits, and the integration of both PREDIMED and VAI in future studies could support more comprehensive strategies for cardiometabolic risk stratification and obesity care.
Authors
- Tommaso Piticchio (ORCID: https://orcid.org/0000-0002-0567-6494)
- Francesco Pallotti (ORCID: https://orcid.org/0000-0001-9946-8516)
- Federica Barbagallo (ORCID: https://orcid.org/0000-0002-2972-370X)
- Rosario Le Moli (ORCID: https://orcid.org/0000-0002-1398-9271)
- Gabriele Costanzo
- Stefano Burgio (ORCID: https://orcid.org/0000-0002-9497-5612)
- Roberto Baratta
- Valentina Paternò
- Giulio Geraci
- Gianluca Sambataro
Institutions
- Università degli Studi di Enna Kore (IT)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Agenzia Regionale Sanitaria della Puglia (IT)
- Azienda di Rilievo Nazionale ed Alta Specializzazione (IT)
- Ospedali Riuniti Umberto I (IT)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fendo.2025.1700894
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca