CDK1-driven phosphorylation networks promote glioblastoma progression via MAP1B-mediated microtubule destabilization

This study demonstrates that CDK1 is a critical oncogenic driver in GBM, regulating broad phosphosignaling networks and promoting tumor progression via MAP1B-dependent microtubule destabilization. MAP1B phosphorylation emerges as a potential prognostic biomarker. These findings support the development of CDK1-targeted therapies, alone or combined with microtubule-stabilizing agents, for improved GBM management.