Cross-lagged panel model of depressive mood and influencing factors in high-risk perinatal depression

This study among high-risk women with PND found that late-pregnancy depression was prospectively associated with higher postpartum cognitive reactivity, perceived stress, and depressive symptoms, and with poorer family function, mindfulness, and sleep quality. These findings advance understanding of the dynamic interplay between perinatal psychological and interpersonal factors and highlight the need for early intervention during pregnancy. Clinically, strengthening depression screening and adopting targeted strategies-such as cognitive-behavioral therapy, family counseling, mindfulness training, and sleep optimization-may aid in the prevention, early detection, and treatment of PND, thereby safeguarding maternal mental health and infant well-being.