25-Hydroxyvitamin D3 metabolism modulates the effect of variable UV exposure on 25-hydroxyvitamin D3 plasma concentrations
The kinetics of 25(OH)D<sub>3</sub> synthesis and degradation modulate the effect of variable UV exposure on 25(OH)D<sub>3</sub> concentrations. This results in a regulated plasma signal reflecting local seasonal parameters. While absolute 25(OH)D<sub>3</sub> concentrations are commonly investigated, future studies should also examine their temporal dynamics as a biological signal.
Authors
- Lars Melholt Rasmussen (ORCID: https://orcid.org/0000-0001-5795-4794)
- Gunga Hc
- Alexander Shinkov (ORCID: https://orcid.org/0000-0002-9203-4149)
- Thomas Wilson (ORCID: https://orcid.org/0000-0003-4197-3362)
- Merike Luman
- Viera Stubnova (ORCID: https://orcid.org/0000-0003-3923-4843)
- Gabriele I. Stangl (ORCID: https://orcid.org/0000-0001-8073-524X)
- Uwe Feister
- Inga Arūnė Bumblytė
- Eleni Geladari
- Petrauskiene
- H. D. Kambezidis (ORCID: https://orcid.org/0000-0003-1249-3140)
- Natalia G. Vallianou (ORCID: https://orcid.org/0000-0003-3874-5393)
- Mathias Steinach (ORCID: https://orcid.org/0000-0002-7457-4301)
- Kristian Assing (ORCID: https://orcid.org/0000-0001-8744-1615)
- G Slavov (ORCID: https://orcid.org/0000-0002-7095-4892)
- Jianlin Shen
- Frank Hirche
- Kyriakos Trigkidis
- Qihua Tan
- Alexandra Scholze
Institutions
- Lithuanian University of Health Sciences (LT)
- Deutscher Wetterdienst (DE)
- University of Southern Denmark (DK)
- Lund University (SE)
- Vestre Viken Hospital Trust (NO)
- Medical University Plovdiv (BG)
- Odense University Hospital (DK)
- Medical University of Sofia (BG)
- Humboldt-Universität zu Berlin (DE)
- North Estonia Medical Centre (EE)
- National Observatory of Athens (GR)
- Hammerfest Hospital (NO)
- Skåne University Hospital (SE)
- Evangelismos Hospital (GR)
- Putian University (CN)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1038/s43856-025-01368-7
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Luft- und Raumfahrt
- Odense Universitetshospital
- Bundesministerium für Wirtschaft und Energie
- Finnmarkssykehuset HF