SLC40A1-mediated positive feedback loop with M1 macrophages suppresses epithelial ovarian cancer progression
These findings identify SLC40A1 as a key regulator of the antitumor immune response in EOC. High SLC40A1 expression is associated with enhanced macrophage-mediated tumor suppression and improved response to immunotherapy, highlighting its potential as both a prognostic biomarker and a therapeutic target.
Authors
- Guangyan Wang
- Fugen Shangguan (ORCID: https://orcid.org/0000-0001-7355-562X)
- A. Li
- Bo Yin (ORCID: https://orcid.org/0000-0002-5889-0339)
- Zhenzhen Xu (ORCID: https://orcid.org/0000-0002-8755-8597)
- Zhexin Xia
- Baoyou Huang
- Yuheng Li
- Sisi Huang
- Yan Hu
- Jinghang Ma
- Honglei Jin
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1709597
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00