Associations of phenotypic age acceleration, genetic risk, and lifestyle with chronic digestive diseases: A large-scale longitudinal cohort study
Higher PhenoAgeAccel was associated with higher risks of chronic digestive diseases, with associations modified by genetic risk and lifestyle. PhenoAgeAccel may be a useful risk marker and warrants further investigation of aging-targeted strategies.
Authors
- Shuai Xiang (ORCID: https://orcid.org/0000-0002-5417-6445)
- Yixuan Li (ORCID: https://orcid.org/0009-0007-6506-4178)
- Yunlong Li
- Xu Che
- Yongxing Du
- Shuzhe Xie
- Chengfeng Wang
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Changzhi Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- National Cancer Center (US)
Publication Details
- Journal
- The journal of nutrition health & aging
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1016/j.jnha.2026.100775
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00