Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's disease
This study reveals an association between GlcSph and dyskinesias in GBA1-PD, that should prompt further investigation to assess the GlcSph role as a possible biomarker and target to tackle dyskinesias in GBA1-PD.
Authors
- Giulia Di Rauso (ORCID: https://orcid.org/0000-0001-7159-9311)
- Ruggero Bacchin
- Maurizio Zibetti (ORCID: https://orcid.org/0000-0002-2939-343X)
- Marcello Mario Mascia (ORCID: https://orcid.org/0000-0002-9028-5972)
- Francesco Cavallieri (ORCID: https://orcid.org/0000-0001-5836-1982)
- Massimo Marano (ORCID: https://orcid.org/0000-0001-9885-3666)
- Gennarina Arabia
- Filippo Tamma
- E. Caputo
- Giovanni Mostile (ORCID: https://orcid.org/0000-0002-3556-7432)
- Federico Reali (ORCID: https://orcid.org/0000-0002-7891-5695)
- Edoardo Monfrini (ORCID: https://orcid.org/0000-0003-4720-9234)
- C Ledda
- Cristiano Sorrentino (ORCID: https://orcid.org/0009-0003-6075-3899)
- Maria Chiara Malaguti (ORCID: https://orcid.org/0000-0002-4807-4063)
- Sara Pietracupa (ORCID: https://orcid.org/0000-0002-7654-291X)
- Roberta Bovenzi (ORCID: https://orcid.org/0009-0004-4824-0051)
- Ilaria Antonella Di Vico (ORCID: https://orcid.org/0000-0001-7126-8686)
- Marco Liccari
- Simone Aloisio (ORCID: https://orcid.org/0009-0006-4675-6059)
- Giulia Bonato
- Rosa De Micco
- Mario Zappia (ORCID: https://orcid.org/0000-0002-0393-4736)
- Roberto Eleopra
- Roberto Erro
- Andrea Pilotto
- Alessandro Magliozzi
- Nicola Modugno
- Giovanni Fabbrini
- Francesca Spagnolo
- Micol Avenali
- Enza Maria Valente
- Carmela Zizzo
- Giulia Franco
- Alessandro Padovani
- Anna Rita Bentivoglio
- Valentina Fioravanti
- Francesca Leo
- Fabiana Colucci
- Alessio Di Fonzo
- Alessandro Lupini
- Tommaso Schirinzi
- Mario Meloni
- Giovanni Duro
- Vincenzo Di Lazzaro
- Alessandro Tessitore
- Michele Tinazzi
- Silvia Ramat
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Rome Tor Vergata (IT)
- University of Verona (IT)
- University of Modena and Reggio Emilia (IT)
- University of Salerno (IT)
- University of Padua (IT)
- University of Trieste (IT)
- Università Campus Bio-Medico (IT)
- University of Trento (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Pavia (IT)
- Foundation Center (US)
- The Microsoft Research - University of Trento Centre for Computational and Systems Biology (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Istituto Neurologico Mediterraneo (IT)
- Magna Graecia University (IT)
- University of Catania (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Maggiore (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Ospedale A. Perrino (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Azienda Ospedaliero-Universitaria Cagliari (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Institute for Biomedical Research and Innovation (IT)
- Campus Bio Medico University Hospital (IT)
- Ospedale Generale Regionale Francesco Miulli (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1016/j.nbd.2026.107271
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00