Association Between Frailty and Leptin Levels in Patients with Stable Coronary Artery Disease

<b>Background/Objectives</b>: The study aimed to examine the association between the total SPPB score and serum leptin levels in patients with coronary artery disease (CAD) undergoing elective percutaneous coronary intervention (PCI). <b>Methods</b>: A cross-sectional study included 204 prospectively enrolled patients with CAD who were admitted for elective PCI. The mean age was 67.45 ± 8.63 years; 63.2% of patients were male. The Short Physical Performance Battery (SPPB) was used to screen for prefrailty and frailty (10-12 points: no frailty; 8-9 points: prefrailty; ≤7 points: frailty). The levels of leptin, a biomarker of fat remodeling, were measured by a highly sensitive and highly specific enzyme immunoassay using a Diagnostics Biochem Canada Inc. Leptin ELISA Kit (London, ON, Canada). <b>Results</b>: The prevalence of frailty and prefrailty in patients with stable CAD was 20.1% and 40.2%, respectively. A comparative analysis revealed that frailty was significantly more likely in older women with CAD before elective PCI. The total serum leptin level was 13.00 [8.00-50.00] ng/mL. Frail patients with CAD had higher leptin levels than patients without frailty (25.40 [7.00-60.00] ng/mL vs. 12.00 [5.15-19.70] ng/mL, <i>p</i> = 0.037). The leptin level in patients with prefrailty was 16.70 [13.00-49.10] ng/mL. Moreover, there was a moderate inverse correlation between the total SPPB score and serum leptin levels before PCI (<i>p</i> = 0.006). A regression analysis found that the total SPPB score in patients with stable CAD was associated with high serum leptin levels (<i>p</i> < 0.001) and older age (<i>p</i> = 0.017). <b>Conclusions</b>: Our study found that frail patients with CAD undergoing PCI had higher serum leptin levels than patients without frailty.