Ethanol extract of Dysosma versipellis induces cytotoxicity in colonic epithelial cells via activation of the PI3K–Akt/MAPK signaling pathways
Oral DV metabolism releases 4'-demethylpodophyllotoxin, activating the PI3K-Akt/MAPK pathway in the colon epithelium and causing transcriptomic-metabolic dysregulation and epithelial necrosis. These findings inform clinical safety and detoxification strategies.
Authors
- Xing Tu (ORCID: https://orcid.org/0000-0003-4354-6698)
- Yingying Yu (ORCID: https://orcid.org/0000-0001-5357-5527)
- Guosheng Liu (ORCID: https://orcid.org/0000-0002-8069-6268)
- Tian Shi (ORCID: https://orcid.org/0000-0002-7857-9759)
- Hao Lei
- Xiao Liu
- Jian Chang
- Shengyao Tang
- Xiangyang Shao
Institutions
- General Administration of Quality Supervision, Inspection and Quarantine (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Minda Hospital (CN)
- The People's Hospital of LinXia (CN)
- Hubei Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s40001-025-03789-5
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.00