Time-dependent diffusion MRI for noninvasive molecular subtype differentiation and biological correlation in breast cancer: emphasizing the emerging three-tier HER2 classification
ADC<sub>30ms</sub> most effectively distinguished HER2-zero from HER2-low tumors, while microstructural parameters such as cellularity and cell diameter moderately differentiated HER2-low from HER2-positive cancers. These results support the potential of T<sub>d</sub>-dMRI as a complementary imaging biomarker for subtype characterization, although findings were limited by small subgroup sizes and the single-center design.
Authors
- Chunmiao Xu (ORCID: https://orcid.org/0000-0003-4064-5447)
- Kuiyuan Liu (ORCID: https://orcid.org/0000-0002-8994-5873)
- Junhui Yuan
- Shouning Zhang
- Mingzhe Xu
- Renzhi Zhang
- Haotian Li
- Dan Wu
- Yue Wu
- Xuejun Chen
Institutions
- Zhejiang A & F University (CN)
- National Cancer Center (US)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fonc.2025.1739008
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00