Moving beyond the empty cell: The threat of decontextualized healthcare data

Missing, inaccurate, or poorly documented data in healthcare is often treated as a technical problem to be statistically resolved via imputation, deletion, or modeling assumptions about randomness. However, such inaccuracies relate to far more complex socioeconomic and geopolitical issues, rather than "errors of data entry" to be ameliorated with statistical modeling techniques. We outline that what is really missing or inaccurate is the context in which the data is collected-and that only by understanding this context can we begin to prevent artificial intelligence's (AIs) amplification of misleading, decontextualized data. We critically examine how traditional modeling methods fail to account for the factors that influence what data gets recorded, and for whom. We show how AI systems trained on decontextualized data reinforce health inequities at scale. And, we review recent literature on context-aware approaches to understanding data, that incorporate metadata, social determinants of health, fairness constraints, and participatory governance to build more ethical and representative systems. Our analysis urges the AI and healthcare communities to move beyond the traditional emphasis on statistical convenience, toward socially grounded and interdisciplinary strategies for handling decontextualized data.

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Publication Details

Journal
PLOS Digital Health
Published
2026-01-13
DOI
https://doi.org/10.1371/journal.pdig.0001194
Primary Topic
Machine Learning in Healthcare
Type
article
Field-Weighted Citation Impact
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article

Moving beyond the empty cell: The threat of decontextualized healthcare data

William Mitchell, Moad Hani, Shaheen Siddiqui, Aya El Mir et al.
PLOS Digital Health
Machine Learning in Healthcare
article

Moving beyond the empty cell: The threat of decontextualized healthcare data

William Mitchell, Moad Hani, Shaheen Siddiqui, Aya El Mir, Neha Nageswaran, Ignacio Mesina-Estarrón, Leo Anthony Celi, Saïd Mahmoudi, Sreeram Sadasivam, Eric Bezerra de Sousa, Mohammed Benjelloun
article en

Abstract

Missing, inaccurate, or poorly documented data in healthcare is often treated as a technical problem to be statistically resolved via imputation, deletion, or modeling assumptions about randomness. However, such inaccuracies relate to far more complex socioeconomic and geopolitical issues, rather than "errors of data entry" to be ameliorated with statistical modeling techniques. We outline that what is really missing or inaccurate is the context in which the data is collected-and that only by understanding this context can we begin to prevent artificial intelligence's (AIs) amplification of misleading, decontextualized data. We critically examine how traditional modeling methods fail to account for the factors that influence what data gets recorded, and for whom. We show how AI systems trained on decontextualized data reinforce health inequities at scale. And, we review recent literature on context-aware approaches to understanding data, that incorporate metadata, social determinants of health, fairness constraints, and participatory governance to build more ethical and representative systems. Our analysis urges the AI and healthcare communities to move beyond the traditional emphasis on statistical convenience, toward socially grounded and interdisciplinary strategies for handling decontextualized data.

PLOS Digital HealthVol. 5(1)
New York University Abu Dhabi (AE), Carl von Ossietzky Universität Oldenburg (DE), Children's Hospital of Orange County (US), University of Mons (BE), Beth Israel Deaconess Medical Center (US), Harvard University (US), Universidade de São Paulo (BR), Cambridge University Hospitals NHS Foundation Trust (GB), Software (Germany) (DE), Koo & Associates International (United States) (US), Massachusetts Institute of Technology (US)
Reduced inequalities
Openalex Percentile: Top 90%
Machine Learning in Healthcare
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