Effects of sheep follicular fluid-derived exosomes and miR-148a on theca cell function in vitro
The above findings indicate that sheep follicular fluid exosomes can significantly enhance follicular membrane cell proliferation and steroid hormone secretion. The miR-148a carried in exosomes can promote the proliferation of TCs by inhibiting the expression of its target gene TGFβ2. This study will help to reveal the molecular mechanism of exosomes in follicular development and provide new perspectives for improving reproductive efficiency and genetic improvement in sheep.
Authors
- Runqing Chi
- Yufang Liu (ORCID: https://orcid.org/0000-0003-0303-7784)
- Feng Xing (ORCID: https://orcid.org/0000-0001-5209-9143)
- Runan Zhang
- Kai Liu
- Mingxing Chu
- Qing Liu
Institutions
- Xinjiang Production and Construction Corps (CN)
- Tarim University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
Publication Details
- Journal
- Biological Research
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s40659-026-00668-z
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00