Double cutoff strategies for plasma pTau217 to predict Tau PET positivity across multiple assay platforms: Tau-enriched and Tau-scarce cohorts for cost-effective clinical use
Double cutoff strategies should be applied with attention to assay platform and cohort context. Accuracy gains were modest, but clinical utility lies in reducing misclassification costs and guiding confirmatory PET use.
Authors
- K. Blennow
- Yuna Gu (ORCID: https://orcid.org/0009-0007-3200-3977)
- Fernando González-Ortiz
- J Lee (ORCID: https://orcid.org/0000-0002-0265-5081)
- Theresa A. Day
- Hyemin Jang (ORCID: https://orcid.org/0000-0002-5697-5128)
- Seo Sw
- Sohyun Yim (ORCID: https://orcid.org/0000-0002-9357-768X)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0002-4206-6214)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Heekyoung Kang (ORCID: https://orcid.org/0000-0003-0287-6818)
- Jun Pyo Kim
- for the ADNI and K-ROAD study group
- Nicholas J. Ashton
- Soyeon Yoon
- Min Young Chun
- Henrik Zetterberg
- Duk L. Na
- Hee Kyung Park
- Michael W. Weiner
- Hee Jin Kim
Institutions
- University of Science and Technology of China (CN)
- Alzheimer's Association (US)
- University of Wisconsin–Madison (US)
- Eli Lilly (United States) (US)
- University of California, San Francisco (US)
- Yonsei University (KR)
- Hong Kong University of Science and Technology (HK)
- Samsung (South Korea) (KR)
- Severance Hospital (KR)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Banner Health (US)
- Sorbonne Université (FR)
- University of Ulsan (KR)
- Korea Pharma (South Korea) (KR)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Banner Sun Health Research Institute (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- Yonsei University Health System (KR)
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1186/s13195-025-01952-y
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00