Double cutoff strategies for plasma pTau217 to predict Tau PET positivity across multiple assay platforms: Tau-enriched and Tau-scarce cohorts for cost-effective clinical use

Double cutoff strategies should be applied with attention to assay platform and cohort context. Accuracy gains were modest, but clinical utility lies in reducing misclassification costs and guiding confirmatory PET use.

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Publication Details

Journal
Alzheimer s Research & Therapy
Published
2026-01-14
DOI
https://doi.org/10.1186/s13195-025-01952-y
Primary Topic
Medical Imaging Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

Double cutoff strategies for plasma pTau217 to predict Tau PET positivity across multiple assay platforms: Tau-enriched and Tau-scarce cohorts for cost-effective clinical use

K. Blennow, Yuna Gu, Fernando González-Ortiz, J Lee et al.
Alzheimer s Research & Therapy
Medical Imaging Techniques and Applications
article

Double cutoff strategies for plasma pTau217 to predict Tau PET positivity across multiple assay platforms: Tau-enriched and Tau-scarce cohorts for cost-effective clinical use

K. Blennow, Yuna Gu, Fernando González-Ortiz, J Lee, Theresa A. Day, Hyemin Jang, Seo Sw, Sohyun Yim, Eun Hye Lee, Daeun Shin, Heekyoung Kang, Jun Pyo Kim, for the ADNI and K-ROAD study group, Nicholas J. Ashton, Soyeon Yoon, Min Young Chun, Henrik Zetterberg, Duk L. Na, Hee Kyung Park, Michael W. Weiner, Hee Jin Kim
article en

Abstract

Double cutoff strategies should be applied with attention to assay platform and cohort context. Accuracy gains were modest, but clinical utility lies in reducing misclassification costs and guiding confirmatory PET use.

Alzheimer s Research & TherapyVol. 18(1)
University of Science and Technology of China (CN), Alzheimer's Association (US), University of Wisconsin–Madison (US), Eli Lilly (United States) (US), University of California, San Francisco (US), Yonsei University (KR), Hong Kong University of Science and Technology (HK), Samsung (South Korea) (KR), Severance Hospital (KR), Stavanger University Hospital (NO), Sahlgrenska University Hospital (SE), Samsung Medical Center (KR), Banner Health (US), Sorbonne Université (FR), University of Ulsan (KR), Korea Pharma (South Korea) (KR), Institut de Myologie (FR), Pitié-Salpêtrière Hospital (FR), UK Dementia Research Institute (GB), Banner Sun Health Research Institute (US), National Hospital for Neurology and Neurosurgery (GB), Institut du Cerveau (FR), Yonsei University Health System (KR), University College London (GB), Indiana University – Purdue University Indianapolis (US), Sungkyunkwan University (KR), University of Gothenburg (SE)
Openalex Percentile: Top 90%
Medical Imaging Techniques and Applications
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