Multimodal analysis of TAAD pathogenesis: SHAP-enhanced interpretable models and single-cell sequencing analysis reveal immune microenvironment alterations
This study uncovered SIX4, SCNN1B, and PCDH11X as critical regulators of TAAD. SIX4 was identified as a key modulator of smooth muscle cell plasticity and immune signaling dynamics. These findings deepen our understanding of TAAD pathogenesis and demonstrate the utility of SHAP-guided models in identifying and prioritizing mechanistic drivers in this complex vascular disease.
Authors
- Dianjun Tang
- Qingwei Gang
- Zhong Wang (ORCID: https://orcid.org/0000-0001-9787-7332)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-7886-6187)
- Shikai Shen
- Dongwen Zhao
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Hongming Wei
Institutions
- Nanfang Hospital (CN)
- Second Hospital of Shandong University (CN)
- First Hospital of China Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1630404
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China