Prognostic value of tumor deposits and their different response to neoadjuvant therapy in locally advanced rectal cancer

The presence of mrTDs and the poor regression of mrTDs in cT3-4N+M0 rectal cancer after neoadjuvant treatment are associated with advanced disease and worse outcome. Patients with ypTDs+ after neoadjuvant therapy have dismal outcome, which call for more innovative treatment.

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Publication Details

Journal
PLoS ONE
Published
2026-01-13
DOI
https://doi.org/10.1371/journal.pone.0340000
Primary Topic
Colorectal Cancer Surgical Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Prognostic value of tumor deposits and their different response to neoadjuvant therapy in locally advanced rectal cancer

Haiyan Chen, Yongrui Bai, Yinjue Yu, Junjun Zhou et al.
PLoS ONE
Colorectal Cancer Surgical Treatments
article

Prognostic value of tumor deposits and their different response to neoadjuvant therapy in locally advanced rectal cancer

Haiyan Chen, Yongrui Bai, Yinjue Yu, Junjun Zhou, Yuhai Bian, Cuiping Yang, Bin Hu, Di Zhou
article en

Abstract

The presence of mrTDs and the poor regression of mrTDs in cT3-4N+M0 rectal cancer after neoadjuvant treatment are associated with advanced disease and worse outcome. Patients with ypTDs+ after neoadjuvant therapy have dismal outcome, which call for more innovative treatment.

PLoS ONEVol. 21(1)
Shanghai Jiao Tong University (CN), Renji Hospital (CN)
Good health and well-being
Openalex Percentile: Top 88%
Colorectal Cancer Surgical Treatments
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