Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure
These findings uncover a zinc-dependent ZFP36L1-regulon that governs hepatocyte fate by repressing p21- and JAG1-driven senescence and NOTCH activation and highlight ZFP36L1 as a promising therapeutic target in ALD.
Authors
- Perry J. Blackshear (ORCID: https://orcid.org/0000-0002-9561-8529)
- David S. Umbaugh (ORCID: https://orcid.org/0000-0002-5327-9020)
- Kuo Du (ORCID: https://orcid.org/0000-0002-1446-4653)
- AM Diehl
- Auinash Kalsotra (ORCID: https://orcid.org/0000-0002-1011-0006)
- Rajesh Kumar Dutta (ORCID: https://orcid.org/0000-0002-1394-0961)
- Seh‐Hoon Oh
- Niansheng Ren
- Liuyang Wang
Institutions
- University of Illinois Urbana-Champaign (US)
- Duke University (US)
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- Gut
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1136/gutjnl-2025-337019
- Citations
- 1
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 36.00