Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients

<i>Ex vivo</i> training of monocytes and bone marrow progenitors from patients with NMTC and CRC results in macrophages with increased proinflammatory cytokine production and differentiation toward an anti-tumoral phenotype. This suggests that trained immunity may be exploited as a potential novel treatment strategy for cancer.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-12-17
DOI
https://doi.org/10.3389/fimmu.2025.1706496
Primary Topic
Immune responses and vaccinations
Type
article
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article

Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients

Martin Jaeger, H. Bonenkamp, Conor P. Delaney, Pepijn van Houten et al.
Frontiers in Immunology
Immune responses and vaccinations
article

Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients

Martin Jaeger, H. Bonenkamp, Conor P. Delaney, Pepijn van Houten, Liesbeth van Emst, Prashant Changoer, Petronella Beatrix Ottevanger, Willem J. M. Mulder, Mihai G. Netea, Mieke W. H. Roeven, Manita E. J. Bremmers, Janneke E. W. Walraven, Willemijn Hobo
article en

Abstract

<i>Ex vivo</i> training of monocytes and bone marrow progenitors from patients with NMTC and CRC results in macrophages with increased proinflammatory cytokine production and differentiation toward an anti-tumoral phenotype. This suggests that trained immunity may be exploited as a potential novel treatment strategy for cancer.

Frontiers in ImmunologyVol. 16
University of Bonn (DE), Radboud University Nijmegen (NL), Iuliu Hațieganu University of Medicine and Pharmacy (RO), University Medical Center (US), Radboud University Medical Center (NL), Radboud Institute for Molecular Life Sciences (NL), Eindhoven University of Technology (NL)
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Openalex Percentile: Top 34%
Immune responses and vaccinations
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Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients — Martin Jaeger, H. Bonenkamp, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS