Advancing the future of prosthetic rehabilitation with Regenerative Peripheral Nerve Interface surgery: Questions and opportunities
RPNI surgery has evolved from proof-of-concept to a feasible, scalable strategy for treating patients with amputations. Future progress will depend on refining patient- and nerve-specific modifications, developing wireless, bidirectional devices that leverage RPNI signal transduction, and addressing reimbursement and training barriers. With continued interdisciplinary collaboration, RPNI surgery is poised to become a critical component of prosthetic rehabilitation.
Authors
- Tian Yucheng
- Ahneesh J. Mohanty (ORCID: https://orcid.org/0000-0002-7131-8775)
- Paul S. Cederna (ORCID: https://orcid.org/0000-0002-6756-7197)
- Toby Chen (ORCID: https://orcid.org/0000-0003-1355-8583)
- Stephen W.P. Kemp
- Theodore A. Kung
Institutions
- University of Michigan (US)
Publication Details
- Journal
- Expert Review of Medical Devices
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1080/17434440.2026.2615785
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00