Longitudinal Analysis of CYFRA 21-1 Levels in Patients with Pulmonary Nodules: Differential Trajectories Between Benign and Malignant Cases and Impact of Tumor Resection
CYFRA 21-1 exhibits substantial within-patient variability over time, with trajectories that reflect disease state and treatment. These findings suggest that longitudinal monitoring of CYFRA 21-1-analogous to PSA velocity in prostate cancer-may offer improved diagnostic and prognostic insight in the evaluation of pulmonary nodules. Further studies in larger cohorts are warranted to validate these findings and explore clinical implementation of CYFRA trajectory analysis.
Authors
- Michael N. Kammer (ORCID: https://orcid.org/0000-0001-7912-8450)
- T. Khalil (ORCID: https://orcid.org/0009-0000-9424-0109)
- Stephen A. Deppen (ORCID: https://orcid.org/0000-0002-3661-662X)
- H Chen
- Thomas A. Lasko (ORCID: https://orcid.org/0000-0003-2300-9529)
- Eric L. Grogan
- Samson Alemu Argaw
- Chen Sheau-Chiann
- Sanja Antic (ORCID: https://orcid.org/0000-0002-6948-8003)
- Bennet A. Landman
- Kevin C. McGann
- Yency J. Forero
- Zuo Lianrui
- Yong Zou
Institutions
- Vanderbilt University (US)
- Centre de Recherches en Cancérologie de Toulouse (FR)
- VA Tennessee Valley Healthcare System (US)
- Vanderbilt Health (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-13
- DOI
- https://doi.org/10.64898/2026.01.10.26343848
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- Vanderbilt University Medical Center