Dual-active clotrimazole–methyl eugenol topical gel: <i>in vitro</i> antibiofilm activity against <i>Candida</i> spp. and benchmarking versus commercial topical antifungals
In vitro, the clotrimazole-methyl eugenol gel showed low MIC/MBIC50 values (including against azole-tolerant C. glabrata), maintained cytocompatibility (>85% viability at MIC/MBIC50), and demonstrated robust pharmaceutical attributes, supporting further in vivo validation for biofilm-associated candidiasis.
Authors
- Jan Masák (ORCID: https://orcid.org/0000-0001-6484-0824)
- Dang Anh Tuan
Institutions
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1093/jambio/lxag015
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00