Interleukin-9 Regulates NF-kB-Mediated Activation of Astrocytes in Multiple Sclerosis Brain
Because GM-CSF production by astrocytes is linked to microglial activation and CNS inflammation, these results indicate that IL-9 regulates the astrocyte-microglia axis and has potential therapeutic anti-inflammatory implications in MS.
Authors
- Chiara Parisi (ORCID: https://orcid.org/0000-0003-1350-3929)
- E. Volpe
- Veronica De Paolis (ORCID: https://orcid.org/0000-0002-7549-0572)
- Susanna Amadio (ORCID: https://orcid.org/0000-0002-9266-4597)
- Gloria Donninelli (ORCID: https://orcid.org/0000-0002-1307-4493)
- Emanuela Colombo (ORCID: https://orcid.org/0000-0001-8754-1739)
- Anthea De Angelis
- Costanza Stacchiotti
- Miriam Cinotti
- Cinthia Farina
- Daniele Tidei
- Cinzia Volonté
- Francesca Ruffini
Institutions
- University of Rome Tor Vergata (IT)
- Vita-Salute San Raffaele University (IT)
- Charles Darwin University (AU)
- IRCCS Ospedale San Raffaele (IT)
- Fondazione Santa Lucia (IT)
- National Research Council (IT)
- Institute of Cell Biology and Neurobiology (IT)
- Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1212/nxi.0000000000200537
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 30.63
Funders
- Fondazione Italiana Sclerosi Multipla
- Imperial College London