The circ_0042103/TAF15/NER axis regulates inflammation and DNA damage in pulpitis
By interacting with TAF15, circ_0042103 reduces the levels of the NER-related proteins ERCC1 and PCNA, leading to increased DNA damage and inflammation in hDPSCs, thereby defining a circ_0042103/TAF15/NER axis in pulpitis progression.
Authors
- Jingkun Zhang (ORCID: https://orcid.org/0000-0001-5310-3028)
- Jialin Zhong (ORCID: https://orcid.org/0000-0002-7813-1807)
- Lin Li (ORCID: https://orcid.org/0000-0003-3840-4265)
- F. C. Lai (ORCID: https://orcid.org/0000-0002-2643-7847)
- Huixian Dong
- Bingtao Wang (ORCID: https://orcid.org/0000-0002-9255-163X)
- Yuhong Li (ORCID: https://orcid.org/0000-0002-6435-2027)
- Yiming Li (ORCID: https://orcid.org/0000-0002-6107-5618)
- Qianzhou Jiang
- Liecong Lin
- Wei Chen
- Meizhen Li
- Xuan Chen
- Yiguo Jiang
Institutions
- Wuhan University (CN)
- Stomatology Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s13287-025-04817-1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Bureau