Network pharmacological analysis, Mendelian randomization analysis and animal experimental reveal the mechanism of Wenxin Granules in inhibiting heart failure after myocardial infarction: apoptosis and inflammation
WXG may reduce inflammatory response and enhance cardioprotection and anti-fibrosis by inhibiting the expression of MAPK signaling pathway and its downstream effect proteins. The cardioprotective effects of WXG may be attributed to its core components, including Astragaloside IV, Paeoniflorin, Liquiritin, Albiflorin, Pratensein 7-O-beta-D-glucopyranoside and Ononin.
Authors
- Fuyuan Zhang (ORCID: https://orcid.org/0000-0002-9910-8681)
- Yixin Liu (ORCID: https://orcid.org/0000-0002-9500-8333)
- Rui Liu (ORCID: https://orcid.org/0000-0001-9886-949X)
- Xuanchun Huang
- Jun Li
- Baohua Li
Institutions
- China Academy of Chinese Medical Sciences (CN)
- China Academy of Traditional Chinese Medicine Hospital of Ophthalmology (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fcvm.2025.1714639
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00