Endocytosis and non-canonical autophagy mediate extracellular histones cytotoxicity in vascular models of sepsis
In summary, this study offers insights into histones' cytotoxicity and functional interactions with the LC3B-mediated, non-canonical autophagy pathway, enhancing our understanding of the molecular bases of sepsis pathophysiology within HUVEC and blood vessel organoids.
Authors
- Gustav Jonsson (ORCID: https://orcid.org/0000-0001-6692-8395)
- Carlos Romá‐Mateo (ORCID: https://orcid.org/0000-0002-7981-7157)
- Kirill Salewskij (ORCID: https://orcid.org/0000-0003-3374-5976)
- Concepción Garcés (ORCID: https://orcid.org/0000-0002-9903-511X)
- Luis Diago-Domingo
- L. R. Rodríguez
- F. V. Pallardó
- J. M. Penninger
- A. J. Ibáñez
- P. Tascón
- G. Herrera
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Institute of Molecular Biotechnology (AT)
- Austrian Academy of Sciences (AT)
- University of British Columbia (CA)
- Universitat de València (ES)
- Instituto de Salud Carlos III (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Stem Cell Institute (PA)
- Vienna Biocenter (AT)
- Innovative Research (United States) (US)
- INCLIVA Health Research Institute (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1650789
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00