Amlodipine: Guardian or Provocateur? Exploring Its Role in Parkinsonism

Abstract Drug-induced parkinsonism (DIP) is a debilitating side effect associated with several classes of medications. Amlodipine is a widely used dihydropyridine calcium channel blocker (CCB) commonly prescribed for hypertension and angina. We present a case of a 62-year-old man who underwent liver transplantation and developed parkinsonism shortly after initiation of amlodipine for hypertension. After ruling out other causes for his neurological presentation, discontinuation of amlodipine resulted in a rapid improvement of symptoms, confirming the diagnosis of DIP. This report highlights the importance of recognizing amlodipine as a potential cause of new onset parkinsonism and underscores the need for further research to understand its effects on the dopaminergic pathway.