β-Human Chorionic Gonadotropin–Secreting Giant Cell Tumor of Bone in the Mandible: Case Report and Comprehensive Literature Review

There is only one other case that has been documented of a β-hCG-producing GCTBoccurring in the base of the skull with secondary aneurysmal bone cyst-like changes.This appears to be the first reported instance of β-hCG-secreting GCTB in the gnathicbones. This case exemplifies the diagnostic challenges of rare presentations of GCTBand alerts clinicians to the potential misleading presentation of hormone expression.

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Publication Details

Journal
Head and Neck Pathology
Published
2026-01-13
DOI
https://doi.org/10.1007/s12105-025-01883-y
Primary Topic
Bone Tumor Diagnosis and Treatments
Type
article
Field-Weighted Citation Impact
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article

β-Human Chorionic Gonadotropin–Secreting Giant Cell Tumor of Bone in the Mandible: Case Report and Comprehensive Literature Review

Andres Flores-Hidalgo, Hether Khosa, Sholeh Bazrafshan
Head and Neck Pathology
Bone Tumor Diagnosis and Treatments
article

β-Human Chorionic Gonadotropin–Secreting Giant Cell Tumor of Bone in the Mandible: Case Report and Comprehensive Literature Review

Andres Flores-Hidalgo, Hether Khosa, Sholeh Bazrafshan
article en

Abstract

There is only one other case that has been documented of a β-hCG-producing GCTBoccurring in the base of the skull with secondary aneurysmal bone cyst-like changes.This appears to be the first reported instance of β-hCG-secreting GCTB in the gnathicbones. This case exemplifies the diagnostic challenges of rare presentations of GCTBand alerts clinicians to the potential misleading presentation of hormone expression.

Head and Neck PathologyVol. 20(1)
University of Cincinnati (US), University of Cincinnati Medical Center (US)
Openalex Percentile: Top 90%
Bone Tumor Diagnosis and Treatments
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