Inflammatory Proteins Mediate the Causal Association between Sleep Traits and Breast Cancer: A Mendelian Randomization Study

Morning chronotype confers protection against BC, whereas prolonged sleep duration elevates the risk of triple-negative and luminal A BC. CXCL11 mediates part of the protective effect of short sleep on luminal A BC. These findings provide evidence-based support for BC prevention strategies focusing on sleep optimization.

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Publication Details

Journal
Lifestyle Genomics
Published
2026-01-13
DOI
https://doi.org/10.1159/000550315
Primary Topic
Sleep and related disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Inflammatory Proteins Mediate the Causal Association between Sleep Traits and Breast Cancer: A Mendelian Randomization Study

Jiawei Zhou, Lijun Mao
Lifestyle Genomics
Sleep and related disorders
article

Inflammatory Proteins Mediate the Causal Association between Sleep Traits and Breast Cancer: A Mendelian Randomization Study

Jiawei Zhou, Lijun Mao
article en

Abstract

Morning chronotype confers protection against BC, whereas prolonged sleep duration elevates the risk of triple-negative and luminal A BC. CXCL11 mediates part of the protective effect of short sleep on luminal A BC. These findings provide evidence-based support for BC prevention strategies focusing on sleep optimization.

Lifestyle GenomicsVol. 19(1)
Taizhou Central Hospital (CN)
Taizhou University
Good health and well-being
Openalex Percentile: Top 91%
Sleep and related disorders
DOIOpen Access PDFOpenAlex
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Inflammatory Proteins Mediate the Causal Association between Sleep Traits and Breast Cancer: A Mendelian Randomization Study — Jiawei Zhou, Lijun Mao · Lifestyle Genomics (2026) | TGRS Research Map | TGRS