Post-marketing safety concerns with trofinetide: a disproportionality analysis of the first therapeutic agent for Rett syndrome based on the FDA adverse event reporting system (FAERS)

This study unveils certain potential risks associated with trofinetide in real-world applications. Medical staffs should pay more attention to AEs of patients on the first month.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-01-14
DOI
https://doi.org/10.3389/fphar.2026.1643906
Primary Topic
Genetics and Neurodevelopmental Disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Post-marketing safety concerns with trofinetide: a disproportionality analysis of the first therapeutic agent for Rett syndrome based on the FDA adverse event reporting system (FAERS)

Xihui Yu, Zhuomiao Lin, Jiahong Zhong, Yaofeng Zhang et al.
Frontiers in Pharmacology
Genetics and Neurodevelopmental Disorders
article

Post-marketing safety concerns with trofinetide: a disproportionality analysis of the first therapeutic agent for Rett syndrome based on the FDA adverse event reporting system (FAERS)

Xihui Yu, Zhuomiao Lin, Jiahong Zhong, Yaofeng Zhang, Hongbo Fu
article en

Abstract

This study unveils certain potential risks associated with trofinetide in real-world applications. Medical staffs should pay more attention to AEs of patients on the first month.

Frontiers in PharmacologyVol. 17
Shantou University (CN), Meizhou City People's Hospital (CN), Second Affiliated Hospital of Shantou University Medical College (CN)
Basic and Applied Basic Research Foundation of Guangdong Province
Good health and well-being
Openalex Percentile: Top 90%
Genetics and Neurodevelopmental Disorders
DOIOpen Access PDFOpenAlex
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