TIMP1 as a context-dependent biomarker linking cancer progression and cardiovascular disorders: a multi-level and bioinformatics study
This multi-level and bioinformatics study identifies TIMP1 as a cross-disease regulator with context-dependent functions. TIMP1 serves as a potential prognostic and diagnostic biomarker in digestive cancers, a therapeutic stratification marker for epigenetic interventions, and a candidate mediator linking tumor biology with cardiovascular disorders such as atherosclerosis and heart failure.
Authors
- Dianhua Zhou
- Jianfang Luo
- Yining Dai
- Ranran Zhang (ORCID: https://orcid.org/0000-0002-5273-3615)
- Sicheng Chen
- Haomin Xie
- Zhenyang Fu
- Weiyi Kong
- Zongrong Lin
Institutions
- The University of Queensland (AU)
- Guangdong Pharmaceutical University (CN)
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Guangdong Academy of Medical Sciences (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1699962
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00