Fetal phthalate exposure and asthma outcomes from infancy to adolescence: Individual participant data meta-analysis in the EU Child Cohort Network
Fetal exposure to higher phthalate concentrations is associated with lung function adaptations, while overall no consistent associations were observed with childhood wheezing or asthma. Future studies are needed to assess the causality of the observed associations, to identify the underlying mechanisms, and to assess potential respiratory consequences in adult life.
Authors
- Carlos Zabaleta
- C. Thomsen
- Tarik Karramass (ORCID: https://orcid.org/0000-0003-1743-7877)
- Elke Rouxel (ORCID: https://orcid.org/0009-0005-5552-261X)
- Marieke Welten (ORCID: https://orcid.org/0000-0003-4351-3757)
- Nuria Güil-Oumrait (ORCID: https://orcid.org/0000-0003-4097-7038)
- Demetris Avraam (ORCID: https://orcid.org/0000-0001-8908-2441)
- Marianna Karachaliou (ORCID: https://orcid.org/0000-0002-3014-0747)
- Sophia M. Blaauwendraad
- Amaia Irizar (ORCID: https://orcid.org/0000-0002-0377-7339)
- Chloe Vainqueur
- Manik Kadawathagedara (ORCID: https://orcid.org/0009-0002-3363-6219)
- Vincent Jaddoe
- Liesbeth Duijts
- Leonardo Trasande
- Amrit Kaur Sakhi
- Antonis Myridakis
- Maria-Jose Lopez-Espinosa
- Paula Carrasco
- Martine Vrijheid
- Charline Warembourg
Institutions
- Universitat Jaume I (ES)
- University of Copenhagen (DK)
- Norwegian Institute of Public Health (NO)
- Inserm (FR)
- Universitat de València (ES)
- École des Hautes Études en Santé Publique (FR)
- Universitat Pompeu Fabra (ES)
- Université Paris Cité (FR)
- Basque Government (ES)
- Instituto de Salud Carlos III (ES)
- Erasmus MC (NL)
- Sorbonne Université (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Université Sorbonne Paris Nord (FR)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Biogipuzkoa Health Research Institute (ES)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- Centre de Recherche Épidémiologie et Statistique (FR)
- Imperial College London (GB)
- Université de Rennes (FR)
- New York University (US)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Environment International
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1016/j.envint.2026.110069
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- HORIZON EUROPE Framework Programme