Sleep neurology: pearls and pitfalls

Sleep disorders are among the most frequent and disabling conditions encountered in neurological practice. Chronic insomnia alone affects approximately 10% of adults, while other sleep disorders, including obstructive sleep apnoea, restless legs syndrome, circadian rhythm disturbances, parasomnias and narcolepsy, are often under-recognised and misdiagnosed. Over-reliance on investigations and inappropriate use of pharmacotherapy represents recurring pitfalls. Cognitive behavioural therapy for insomnia remains the gold-standard first-line therapy, yet access is limited and medications are frequently started prematurely. Advances in therapeutics, including dual orexin receptor antagonists for insomnia and orexin-based therapies for narcolepsy, offer new opportunities but require careful integration into practice. Management of restless legs syndrome remains an area where inappropriate use of medications-particularly dopamine agonists-can worsen outcomes. This review highlights common diagnostic and therapeutic pitfalls across the spectrum of sleep disorders, integrates emerging evidence and provides practical strategies for neurologists to optimise care.

Authors

Institutions

Publication Details

Journal
Practical Neurology
Published
2026-01-12
DOI
https://doi.org/10.1136/pn-2025-004688
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Sleep neurology: pearls and pitfalls

Mohammad Hijaz Adenan, Guy D. Leschziner, Laura Pérez Carbonell
Practical Neurology
Sleep and Wakefulness Research
article

Sleep neurology: pearls and pitfalls

Mohammad Hijaz Adenan, Guy D. Leschziner, Laura Pérez Carbonell
article en

Abstract

Sleep disorders are among the most frequent and disabling conditions encountered in neurological practice. Chronic insomnia alone affects approximately 10% of adults, while other sleep disorders, including obstructive sleep apnoea, restless legs syndrome, circadian rhythm disturbances, parasomnias and narcolepsy, are often under-recognised and misdiagnosed. Over-reliance on investigations and inappropriate use of pharmacotherapy represents recurring pitfalls. Cognitive behavioural therapy for insomnia remains the gold-standard first-line therapy, yet access is limited and medications are frequently started prematurely. Advances in therapeutics, including dual orexin receptor antagonists for insomnia and orexin-based therapies for narcolepsy, offer new opportunities but require careful integration into practice. Management of restless legs syndrome remains an area where inappropriate use of medications-particularly dopamine agonists-can worsen outcomes. This review highlights common diagnostic and therapeutic pitfalls across the spectrum of sleep disorders, integrates emerging evidence and provides practical strategies for neurologists to optimise care.

Practical Neurology
Guy's and St Thomas' NHS Foundation Trust (GB), St. Thomas Hospital (CA), National Hospital for Neurology and Neurosurgery (GB), University College London (GB)
Openalex Percentile: Top 90%
Sleep and Wakefulness Research
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Sleep neurology: pearls and pitfalls — Mohammad Hijaz Adenan, Guy D. Leschziner, et al. · Practical Neurology (2026) | TGRS Research Map | TGRS