Sleep neurology: pearls and pitfalls
Sleep disorders are among the most frequent and disabling conditions encountered in neurological practice. Chronic insomnia alone affects approximately 10% of adults, while other sleep disorders, including obstructive sleep apnoea, restless legs syndrome, circadian rhythm disturbances, parasomnias and narcolepsy, are often under-recognised and misdiagnosed. Over-reliance on investigations and inappropriate use of pharmacotherapy represents recurring pitfalls. Cognitive behavioural therapy for insomnia remains the gold-standard first-line therapy, yet access is limited and medications are frequently started prematurely. Advances in therapeutics, including dual orexin receptor antagonists for insomnia and orexin-based therapies for narcolepsy, offer new opportunities but require careful integration into practice. Management of restless legs syndrome remains an area where inappropriate use of medications-particularly dopamine agonists-can worsen outcomes. This review highlights common diagnostic and therapeutic pitfalls across the spectrum of sleep disorders, integrates emerging evidence and provides practical strategies for neurologists to optimise care.
Authors
- Mohammad Hijaz Adenan
- Guy D. Leschziner (ORCID: https://orcid.org/0000-0001-8799-7226)
- Laura Pérez Carbonell
Institutions
- Guy's and St Thomas' NHS Foundation Trust (GB)
- St. Thomas Hospital (CA)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Practical Neurology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1136/pn-2025-004688
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00