Antibody levels to variant and conserved Plasmodium falciparum antigens predict reduction in parasite burden in Malian children
The study showed that high antibody levels against four proteins significantly reduced the odds of high parasite burden in future infections. Our functional study suggests that opsonic phagocytosis may mediate reduction in parasite density by antibodies to DBLγ11 and DBLζ5.
Authors
- Santosh A. Misal (ORCID: https://orcid.org/0000-0002-8835-0130)
- Delesa Damena (ORCID: https://orcid.org/0000-0002-4594-713X)
- Santara Gaoussou
- Jonathan P. Renn
- Alimou Barry
- Almahamoudou Mahamar
- Michal Fried
- Lauren Dang
- Patrick E. Duffy
- Djibrilla Issiaka
- Robert D. Morrison
- Alassane Dicko
Institutions
- University of Bamako (ML)
- Université des Sciences, des Techniques et des Technologies de Bamako (ML)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1745097
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health