A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
Together, these findings highlight novel neuroprotective effects of Neurosyn240 in modulating metabolite-mediated pathways of the microbiota-gut-brain axis, accentuating its therapeutic potential against AD progression.
Authors
- Gwénaëlle Le Gall (ORCID: https://orcid.org/0000-0002-1379-2196)
- Emily Connell (ORCID: https://orcid.org/0000-0002-1232-3945)
- Line Pourtau (ORCID: https://orcid.org/0000-0003-3315-2222)
- David Vauzour (ORCID: https://orcid.org/0000-0001-5952-8756)
- Marrium Liaquat (ORCID: https://orcid.org/0000-0001-7290-2554)
- Matthew G. Pontifex (ORCID: https://orcid.org/0000-0003-2174-2313)
- Léonie Láng (ORCID: https://orcid.org/0009-0008-6725-663X)
- Michael Müller (ORCID: https://orcid.org/0000-0002-5930-9905)
- Bernadette Breeze
- Simon McArthur
- Saber Sami
- David Gaudout
Institutions
- University of East Anglia (GB)
- Queen Mary University of London (GB)
- Association Clinique et Thérapeutique Infantile du Val de Marne (FR)
Publication Details
- Journal
- Gut Microbes
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1080/19490976.2026.2614030
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00