5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice
These findings uncover the role of 5-HT2C receptors in DRN glutamatergic neurons in pain-anxiety comorbidity, thereby presenting novel targets for potential therapeutic interventions.
Authors
- Changmao Zhu
- Siqi Yang (ORCID: https://orcid.org/0009-0000-3057-1160)
- Chaoli Huang
- Riyue Jiang (ORCID: https://orcid.org/0009-0000-5859-7944)
- Zifeng Wu (ORCID: https://orcid.org/0009-0003-0774-0597)
- Yuanyuan Wang
- Di Wang
- Suwan Hu
- Xinying Zhang
- Chun Yang
- Ling Yang
- Qi Zhang
- Li Xie
- Jingyao Huang
- Yawei Ji
Institutions
- Tougaloo College (US)
- Soochow University (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s12916-026-04620-6
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00