Ferroptosis inhibits cementoblast mineralization via cGAS-STING/GPX4 axis

Compressive force inhibits cementoblast mineralization by inducing ferroptosis via the cGAS-STING/GPX4 axis. Furthermore, H-151 effectively suppresses OIIERR in mice. Targeting cGAS-STING/GPX4 axis-mediated ferroptosis may serve as a potential therapeutic strategy for OIIERR treatment.

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Publication Details

Journal
Progress in Orthodontics
Published
2026-01-13
DOI
https://doi.org/10.1186/s40510-026-00607-4
Primary Topic
interferon and immune responses
Type
article
Field-Weighted Citation Impact
0.00

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article

Ferroptosis inhibits cementoblast mineralization via cGAS-STING/GPX4 axis

Dongyang Li, Chunmiao Jiang, Zhe Zhou, TIAN Wei et al.
Progress in Orthodontics
interferon and immune responses
article

Ferroptosis inhibits cementoblast mineralization via cGAS-STING/GPX4 axis

Dongyang Li, Chunmiao Jiang, Zhe Zhou, TIAN Wei, Jie M. Zhang
article en

Abstract

Compressive force inhibits cementoblast mineralization by inducing ferroptosis via the cGAS-STING/GPX4 axis. Furthermore, H-151 effectively suppresses OIIERR in mice. Targeting cGAS-STING/GPX4 axis-mediated ferroptosis may serve as a potential therapeutic strategy for OIIERR treatment.

Progress in OrthodonticsVol. 27(1)
Qingdao University (CN), Affiliated Hospital of Qingdao University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Shandong Province
Openalex Percentile: Top 89%
interferon and immune responses
DOIOpen Access PDFOpenAlex
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