Exploratory Biomarker Analysis of Abemaciclib in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma With Dysregulated <scp>CDK4</scp> /6 Pathway

Although abemaciclib resulted in limited tumor regression, CDKN2A deletion may be a predictive biomarker for prolonged disease stabilization. Further investigations on genomically selected populations and combination strategies are required.

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Publication Details

Journal
Head & Neck
Published
2026-01-13
DOI
https://doi.org/10.1002/hed.70165
Primary Topic
Advanced Breast Cancer Therapies
Type
article
Field-Weighted Citation Impact
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article

Exploratory Biomarker Analysis of Abemaciclib in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma With Dysregulated CDK4 /6 Pathway

K. Park, B. Keam, Sang‐Gon Park, Hyo Jung Kim et al.
Head & Neck
Advanced Breast Cancer Therapies
article

Exploratory Biomarker Analysis of Abemaciclib in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma With Dysregulated CDK4 /6 Pathway

K. Park, B. Keam, Sang‐Gon Park, Hyo Jung Kim, Joo‐Hwan Park, hwan jung yun, T. Yun, Hye Ryun Kim, Sang‐Cheol Lee, Sang Hee Cho, Hee Kyung Ahn, Soyeon Kim
article en

Abstract

Although abemaciclib resulted in limited tumor regression, CDKN2A deletion may be a predictive biomarker for prolonged disease stabilization. Further investigations on genomically selected populations and combination strategies are required.

Head & Neck
Seoul National University (KR), Yonsei University (KR), Soonchunhyang University (KR), Samsung Medical Center (KR), Seoul National University Hospital (KR), Gachon University Gil Medical Center (KR), National Cancer Center (US), Chonnam National University Hospital (KR), Chosun University Hospital (KR), National Cancer Center (KR), Chungnam National University Hospital (KR), Sacred Heart Hospital (US), Hallym University Sacred Heart Hospital (KR), Keimyung University (KR)
Openalex Percentile: Top 90%
Advanced Breast Cancer Therapies
DOISourceOpenAlex
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Exploratory Biomarker Analysis of Abemaciclib in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma With Dysregulated <scp>CDK4</scp> /6 Pathway — K. Park, B. Keam, et al. · Head & Neck (2026) | TGRS Research Map | TGRS