Clinical utility of serial plasma cell-free DNA metagenomic next-generation sequencing assays
This single center retrospective observational study of serial plasma metagenomic next-generation sequencing testing shows that >95% of serial testing was without meaningful clinical impact. Only 5/173 cases were adjudicated as having significant clinical impact.
Authors
- Daniel Z. Uslan (ORCID: https://orcid.org/0000-0002-9800-3482)
- Shangxin Yang (ORCID: https://orcid.org/0000-0001-9991-1178)
- Bennett Shaw (ORCID: https://orcid.org/0000-0002-0180-6802)
- Kavitha Prabaker
- Christopher Tymchuk
- Timothy F. Brewer (ORCID: https://orcid.org/0000-0002-5615-1639)
- Sanchi Malhotra (ORCID: https://orcid.org/0000-0002-2485-3927)
- Huan Vinh Dong (ORCID: https://orcid.org/0000-0002-6370-1811)
- Ishminder Kaur (ORCID: https://orcid.org/0000-0002-1759-8788)
- Tawny Saleh
- Christy Lukose
- Helen Zhou
- Young Bo Sim
Institutions
- University of California System (US)
Publication Details
- Journal
- Infection Control and Hospital Epidemiology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1017/ice.2025.10390
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health