Hyperbranched polymer functionalized antimicrobial fibrous membranes

Emergence of microbial, viral, and airborne pollutants is a global issue, especially in the current environment. Advanced hybrid multifunctional fibers, owing to their excellent sorption activity and nanostructure dependent properties, have proven to be more effective than existing microstructure filtration membranes. Here, multifunctional fibers are fabricated using a combination of fifth generation linear-dendritic HBPs (hyperbranched polymers) furnished with either cationic ammonium or anionic carboxyl groups within a biodegradable and biocompatible poly(L-lactide-co-caprolactone) (PLCL) polymer. Morphological and physicochemical analysis confirmed the generation of fiber via electrospinning. The average diameter of NH 3 + HBP functionalized PLCL was 0.65 ± 0.29 μm, and COOH HBP functionalized PLCL was 0.91 ± 0.46 μm. The antibacterial evaluation results against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) show an effectiveness exceeding 99.9 %. Electrospun fibers show a significant antiviral efficacy against Coronavirus (OC43), exceeding 97 %. However, the effectiveness against other types of viruses needs further study. Nevertheless, the scalability of the fabrication methodology and the antibacterial efficacy of these novel compositions have the potential to supplement the already existing filtration membranes and overcome the problem of pollutants in a closed environment.

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Publication Details

Journal
Hybrid Advances
Published
2026-01-13
DOI
https://doi.org/10.1016/j.hybadv.2026.100612
Primary Topic
Electrospun Nanofibers in Biomedical Applications
Type
article
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article

Hyperbranched polymer functionalized antimicrobial fibrous membranes

Eva Filová, Viraj P. Nirwan, Núria Portoles Gil, Michael Malkoch et al.
Hybrid Advances
Electrospun Nanofibers in Biomedical Applications
article

Hyperbranched polymer functionalized antimicrobial fibrous membranes

Eva Filová, Viraj P. Nirwan, Núria Portoles Gil, Michael Malkoch, Jamie E. Godfrey, Thomas Martinez, Amir Fahm
article en

Abstract

Emergence of microbial, viral, and airborne pollutants is a global issue, especially in the current environment. Advanced hybrid multifunctional fibers, owing to their excellent sorption activity and nanostructure dependent properties, have proven to be more effective than existing microstructure filtration membranes. Here, multifunctional fibers are fabricated using a combination of fifth generation linear-dendritic HBPs (hyperbranched polymers) furnished with either cationic ammonium or anionic carboxyl groups within a biodegradable and biocompatible poly(L-lactide-co-caprolactone) (PLCL) polymer. Morphological and physicochemical analysis confirmed the generation of fiber via electrospinning. The average diameter of NH 3 + HBP functionalized PLCL was 0.65 ± 0.29 μm, and COOH HBP functionalized PLCL was 0.91 ± 0.46 μm. The antibacterial evaluation results against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) show an effectiveness exceeding 99.9 %. Electrospun fibers show a significant antiviral efficacy against Coronavirus (OC43), exceeding 97 %. However, the effectiveness against other types of viruses needs further study. Nevertheless, the scalability of the fabrication methodology and the antibacterial efficacy of these novel compositions have the potential to supplement the already existing filtration membranes and overcome the problem of pollutants in a closed environment.

Hybrid AdvancesVol. 12
Institute of Microbiology (BY), Teknikföretagen (Sweden) (SE), Leitat Technological Center (ES), Czech Academy of Sciences, Institute of Experimental Medicine (CZ), Rhine-Waal University of Applied Sciences (DE)
Openalex Percentile: Top 90%
Electrospun Nanofibers in Biomedical Applications
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Hyperbranched polymer functionalized antimicrobial fibrous membranes — Eva Filová, Viraj P. Nirwan, et al. · Hybrid Advances (2026) | TGRS Research Map | TGRS