Influence of anesthetic agent and burst suppression on postoperative delirium in elderly patients: a prospective cohort study with automated EEG analysis
Sevoflurane markedly increased POD risk versus propofol, independent of BS duration. Sevoflurane and BS interaction amplified delirium odds. BS appears a vulnerability marker rather than a causal factor. The validated machine-learning BS detector offers a reliable tool for future EEG-based delirium risk research.
Authors
- Marc Dorenbeck
- Sophie Leroy (ORCID: https://orcid.org/0009-0007-5302-2763)
- Susanne Koch
- Vera Röhr
- Maximilian Markus
- Claudia Spies
- Emery N. Brown
- Benjamin Blankertz
Institutions
- Harvard University (US)
- Humboldt-Universität zu Berlin (DE)
- Massachusetts General Hospital (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Technische Universität Berlin (DE)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fnagi.2025.1743267
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft