Si-Ni-San improves the deposition of lipid droplets in MAFLD through modulating the FXR-GPAT4 axis
This study provided a new mechanistic exploration for FXR in improving MAFLD and broadened the research direction on the mechanisms by which SNS reduced hepatic lipid droplets deposition. It also offers a molecular dynamics basis for subsequent studies on how active components in SNS exert their effects through binding to FXR.
Authors
- Yongmin Li (ORCID: https://orcid.org/0009-0001-3702-0043)
- Xuelun Wang
- Haibo Fan
- Yue Li
- Zhiwen Zheng
- Yunfeng Li
- Yalei Hou
Institutions
- Hospital of Hebei Province (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s13020-025-01309-5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00