Hemorrhagic risk of concomitant direct oral anticoagulants and fluoroquinolones: integration of pharmacovigilance and therapeutic drug monitoring

This integrated analysis provides suggestive evidence for a pharmacokinetically plausible interaction that may increase the reporting odds of bleeding between dabigatran and certain FQNs (e.g., levofloxacin). Other DOACs appear safer with FQNs coadministration. For dabigatran patients requiring FQNs, alternative agents or enhanced monitoring should be considered.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-01-13
DOI
https://doi.org/10.3389/fphar.2026.1745035
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

Hemorrhagic risk of concomitant direct oral anticoagulants and fluoroquinolones: integration of pharmacovigilance and therapeutic drug monitoring

Chun-Yan Duan, Fenglun Zhao, Jiao Xu, Zhu Zhu et al.
Frontiers in Pharmacology
Atrial Fibrillation Management and Outcomes
article

Hemorrhagic risk of concomitant direct oral anticoagulants and fluoroquinolones: integration of pharmacovigilance and therapeutic drug monitoring

Chun-Yan Duan, Fenglun Zhao, Jiao Xu, Zhu Zhu, Zhan-hong Hu, Zi-yi Shang, Jun-ping Han, Yue-dong Li
article en

Abstract

This integrated analysis provides suggestive evidence for a pharmacokinetically plausible interaction that may increase the reporting odds of bleeding between dabigatran and certain FQNs (e.g., levofloxacin). Other DOACs appear safer with FQNs coadministration. For dabigatran patients requiring FQNs, alternative agents or enhanced monitoring should be considered.

Frontiers in PharmacologyVol. 17
Soochow University (CN), Second Affiliated Hospital of Soochow University (CN)
Jiangsu Hengrui Medicine, Jiangsu Pharmaceutical Association, Soochow University, U.S. Food and Drug Administration
Good health and well-being
Openalex Percentile: Top 90%
Atrial Fibrillation Management and Outcomes
DOIOpen Access PDFOpenAlex
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Hemorrhagic risk of concomitant direct oral anticoagulants and fluoroquinolones: integration of pharmacovigilance and therapeutic drug monitoring — Chun-Yan Duan, Fenglun Zhao, et al. · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS