Decoupling Radical Generation and Copper Catalysis for the Remote C–H Cyanation of Unfunctionalized Sulfonamides
A decoupled photoredox/copper dual catalytic system for the remote C(sp<sup>3</sup>)-H cyanation of aliphatic sulfonamides is described. The strategy circumvents the need for substrate prefunctionalization, a limitation of previous "coupled" systems. An acridinium photocatalyst generates a nitrogen radical from a free N-H bond, while an independent copper cycle, sustained by an external oxidant, forges the C-CN bond with high δ-selectivity.
Authors
- Zhenkun Chen
- Yali He
- Jianjun Li (ORCID: https://orcid.org/0000-0002-6531-3687)
- Jue Wang (ORCID: https://orcid.org/0009-0008-0690-105X)
- Luwei Tong
- Chaodong Wang
Institutions
- Quzhou College of Technology (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c05382
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00