Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis
Groen et al. identify neutralizing interferon-λ2/3 autoantibodies in 11.8% of individuals with cystic fibrosis, a greater than 10-fold higher prevalence than in control individuals. Autoantibody-containing plasmas enhanced respiratory virus replication in vitro, and associated with allergic rhinitis in patients, suggesting that interferon-λ2/3 autoantibodies have the potential to impact mucosal pathology.
Authors
- Marc Emmenegger (ORCID: https://orcid.org/0000-0002-6073-8811)
- E. Bruscia
- Kevin Groen (ORCID: https://orcid.org/0000-0001-6352-1346)
- Johannes Trück (ORCID: https://orcid.org/0000-0002-0418-7381)
- Marie E. Egan (ORCID: https://orcid.org/0000-0002-0567-6048)
- Roger Kuratli
- Benjamin G. Hale
- Chau Tran
Institutions
- University of Zurich (CH)
- University Hospital of Basel (CH)
- Yale University (US)
- University Children's Hospital Zurich (CH)
- Institute of Virology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- Journal of Human Immunity
- Published
- 2025-12-24
- DOI
- https://doi.org/10.70962/jhi.20250268
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00